What is the most important information I should know about trandolapril?
Do not use if you are pregnant, and tell your doctor right away if you become pregnant.
If you have diabetes, do not use trandolapril together with any medication that contains aliskiren (a blood pressure medicine).
Do not take trandolapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
What is trandolapril?
Trandolapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.
Trandolapril is used to treat high blood pressure (hypertension), and to improve survival after a heart attack.
Trandolapril may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking trandolapril?
You should not use trandolapril if you are allergic to it, or if you:
- have a history of angioedema;
- recently took a heart medicine called sacubitril; or
- are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, or ramipril.
Do not take trandolapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use trandolapril together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking trandolapril with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
- kidney disease (or if you are on dialysis);
- liver disease;
- heart disease or congestive heart failure;
- diabetes; or
- if you are on a low-salt diet.
Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Trandolapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breastfeed while using this medicine.
How should I take trandolapril?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Trandolapril can be taken with or without food.
Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking trandolapril. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.
Your blood pressure will need to be checked often. Your kidney function and electrolytes may also need to be checked.
If you need surgery, tell the surgeon ahead of time that you are using trandolapril.
If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking trandolapril?
Do not use potassium supplements or salt substitutes, unless your doctor has told you to.
What are the possible side effects of trandolapril?
Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Call your doctor at once if you have:
- a light-headed feeling, like you might pass out;
- upper stomach pain, and jaundice (yellowing of the skin or eyes);
- chest pain, pounding heartbeats or fluttering in your chest;
-
high potassium level --nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
-
kidney problems --little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
-
low white blood cell counts --fever, chills, feeling light-headed, mouth sores, skin sores, sore throat, cough, trouble breathing; or
-
lung problems --anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus.
Common side effects may include:
- cough;
- dizziness; or
- diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect trandolapril?
Tell your doctor about all your current medicines and any you start or stop using, especially:
- a diuretic or "water pill";
- gold injections to treat arthritis;
- insulin or oral diabetes medicine;
- lithium; or
-
NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may affect trandolapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Where can I get more information?
Your pharmacist can provide more information about trandolapril.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2022 Cerner Multum, Inc. Version: 14.01. Revision date: 10/23/2019.
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